CID 16020046
CID 16020046
CAS: 834903-43-4
Molecular Formula: C25H19N3O4
CID 16020046 - Names and Identifiers
CID 16020046 - Physico-chemical Properties
| Molecular Formula | C25H19N3O4 |
| Molar Mass | 425.44 |
| Density | 1.425±0.06 g/cm3(Predicted) |
| Boling Point | 748.1±60.0 °C(Predicted) |
| Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | 4.27±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | CID16020046 antagonized agonist-induced receptor activation in yeast cells expressing gpr55. CID16020046 antagonized LPI-mediated calcium release and activation of extracellular signal-regulated kinase in HEK293 cells stably expressing human gpr55, however, there was no such effect in HEK293 cells expressing CB1 or CB2. CID16020046 concentration-dependently inhibits LPI-induced activation of NFAT, NF-κB and seroreactive elements, inhibits translocation of NFAT and NF-κB and internalization of gpr55. |
| In vivo study | In a model of intestinal inflammation, CID16020046 improves the inflammatory response and reduces pro-inflammatory cytokines. CID16020046 did not alter exercise and Anxiety behavior in healthy mice. |
CID 16020046 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
CID 16020046 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.351 ml | 11.753 ml | 23.505 ml |
| 5 mM | 0.47 ml | 2.351 ml | 4.701 ml |
| 10 mM | 0.235 ml | 1.175 ml | 2.351 ml |
| 5 mM | 0.047 ml | 0.235 ml | 0.47 ml |
Last Update：2024-01-02 23:10:35
CID 16020046 - Reference Information
| description | CID 16020046 is a GPR55 selective antagonist. It inhibits lpi-induced Ca2 + signaling, ERK1/2 phosphorylation, and gpr55-mediated activation of transcription factors. It has weak inhibitory effect on acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. It reduces the lpi-induced internalization of GPR55. |
| biological activity | CID16020046 (C390-0219) is a selective GPR55 antagonist, which can inhibit the inherent activity of GPR55. IC50 is 0.15 μM in yeast. CID16020046 has only weak activity on other GPCRs, ion channels, kinases and nuclear receptors. |
| target | TargetValue GPR55 (in east) 0.15 μM |
| Target | Value |
| GPR55 (in yeast) | 0.15 μM |
| In vitro study | In yeast cells expressing GPR55, CID16020046 can antagonize receptor activation induced by agonists. CID16020046 antagonized LPI-mediated calcium release and extracellular signal-regulated kinase activation in HEK293 cells stably expressing human GPR55, but not in HEK293 cells expressing CB1 or CB2. CID16020046 concentration-dependent inhibition of LPI-induced activation of NFAT, NF-κB and serum response elements, inhibition of NFAT and NF-κB translocation and internalization of GPR55. |
| in vivo study | in intestinal inflammation model, CID16020046 improve inflammatory response and reduce pro-inflammatory cytokines. CID16020046 did not change the exercise and anxiety behaviors of healthy mice. |
Last Update：2024-04-09 21:54:55
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View History
CID 16020046
5-BROMOVALERYL CHLORIDE
Violet BS
DISTEARYLDIMETHYLAMMONIUM CHLORIDE 75 % IN 2-PROPANOL/WATER
Sulfinyl chloride
Corynoline acetate
5-BROMOVALERYL CHLORIDE
Violet BS
DISTEARYLDIMETHYLAMMONIUM CHLORIDE 75 % IN 2-PROPANOL/WATER
Sulfinyl chloride
Corynoline acetate